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UroToday.com - Past studies have suggested that there is a linkage between the development of renal cell carcinoma (RCC) and the incidence of other secondary malignancies, but this remains controversial. Rabbani and associates out of Memorial Sloan Kettering published a study that suggested that patients with papillary RCC had a higher risk of developing bladder and prostate cancer. In this study, Thompson and colleagues out of the Mayo Clinic examine a cohort of 2722 patients with RCC to determine whether these patients had a higher incidence of other cancers. Their cohort of patients underwent nephrectomy for sporadic RCC over a 30 year period. 80.4% had clear cell, 13.9% papillary, and 4.7% had chromophobe histologies. The authors found that patients with papillary histology were more likely to have colon cancer (p=0.041), prostate cancer (p=0.003), any second malignancy (p<0.001), and multiple malignancies (p<0.001) when compared to patients with clear cell histology. Patients with chromophobe RCC were more likely to have colon cancer (p=0.020) when compared to patients with clear cell histology. Patients with papillary histology were more likely to have bladder cancer, but the incidence did not differ significantly when compared to the other RCC histologies. These data suggest that patients with non-clear cell histology, particularly papillary histology, have a higher incidence of secondary malignancies, when compared to patients with clear cell RCC. This could have implications with regards to screening patients for the development of second malignancies during the follow-up for their RCC. J Urol 176(3): 900-904. Reviewed by UroToday.com Contributing Editor Christopher G. Wood, MD, FACS UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.
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